Microglia and Inflammatory Responses in Diabetic Retinopathy

The Role of Microglia in Diabetic Retinopathy

There is growing evidence that chronic inflammation plays a role in both the development and progression of diabetic retinopathy. There is also evidence that molecules produced as a result of hyperglycemia can activate microglia. However the exact contribution of microglia, the resident immune cells of the central nervous system, to retinal tissue damage during diabetes remains unclear. Current...

Regulatory role of microRNA on inflammatory responses of diabetic retinopathy

Müller Cell–Microglia Cross Talk Drives Neuroinflammation in Diabetic Retinopathy

Diabetic retinopathy (DR) is the most common complication of diabetes and a leading cause of vision loss worldwide (1). Unfortunately, there are no treatments targeting early stages of the disease prior to the onset of sight-threatening vascular defects such as macular edema or neovascularization. A better understanding of the etiology of DR is needed to identify therapeutic targets to halt ear...

Diabetic Retinopathy: Vascular and Inflammatory Disease

Diabetic retinopathy (DR) is the leading cause of visual impairment in the working-age population of the Western world. The pathogenesis of DR is complex and several vascular, inflammatory, and neuronal mechanisms are involved. Inflammation mediates structural and molecular alterations associated with DR. However, the molecular mechanisms underlying the inflammatory pathways associated with DR ...

Anti-Inflammatory Therapy in Diabetic Retinopathy

The concequence of type 1 (T1DM) and type 2 diabetes mellitus (T2DM) is the development of chronic vascular complications encompassing micro-as well as macrocircula-tion. Diabetic retinopathy (DR), microvascular and visually devastating diabetic complication, is estimated to be the leading cause of blindness in working-aged adults in the developed countries, and this upward trend is continuing....